A Project Management Office (PMO) and an Enterprise Project Management Office (EPMO) are both centralized groups within an organization that provide project management guidance and support to ensure that projects align with the organization's goals and objectives. However, there are some key differences between these two types of offices.

A PMO typically focuses on managing projects within a specific business unit or department, while an EPMO has a broader scope and oversees all projects across the organization. An EPMO is responsible for developing and implementing a standardized approach to project management across the organization, including processes, tools, and templates.

The primary responsibilities of a PMO include providing project management guidance and support, monitoring project performance, and ensuring that projects are aligned with the goals and objectives of the business unit. The PMO also facilitates communication and collaboration between project teams, stakeholders, and senior management.

The responsibilities of an EPMO, on the other hand, are much broader. In addition to the responsibilities of a PMO, an EPMO is also responsible for developing and implementing a project management methodology that is used across the entire organization. The EPMO ensures that all projects are aligned with the organization's strategic goals and objectives and that projects are prioritized and resourced appropriately.

An EPMO also typically has more authority and influence within the organization than a PMO. It has a higher level of oversight and governance over projects and may be responsible for strategic planning and decision-making related to project portfolios. An EPMO may also be responsible for managing the organization's project management resources, including project managers and other project management professionals.

In summary, while a PMO and an EPMO share many similarities, an EPMO has a broader scope and is responsible for overseeing all projects across the organization, while a PMO typically focuses on managing projects within a specific business unit or department.